Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed SAMP8 Mice.
Identifieur interne : 000416 ( Main/Exploration ); précédent : 000415; suivant : 000417Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed SAMP8 Mice.
Auteurs : Shintaro Onishi [Japon] ; Shinichi Meguro [Japon] ; Monira Pervin [Japon] ; Hidefumi Kitazawa [Japon] ; Ai Yoto [Japon] ; Mayu Ishino [Japon] ; Yuki Shimba [Japon] ; Yusuke Mochizuki [Japon] ; Shinji Miura [Japon] ; Ichiro Tokimitsu [Japon] ; Keiko Unno [Japon]Source :
- Nutrients [ 2072-6643 ] ; 2019.
Descripteurs français
- KwdFr :
- Alimentation riche en graisse (effets indésirables), Animaux (MeSH), Chimie du cerveau (MeSH), Dysfonctionnement cognitif (traitement médicamenteux), Dysfonctionnement cognitif (étiologie), Encéphale (anatomopathologie), Encéphalopathies (physiopathologie), Encéphalopathies (traitement médicamenteux), Encéphalopathies (étiologie), Extraits de plantes (administration et posologie), Facteur neurotrophique dérivé du cerveau (analyse), Homologue-4 de la protéine Disks Large (analyse), Mâle (MeSH), Mémoire (MeSH), Neuroprotecteurs (MeSH), Peptides bêta-amyloïdes (analyse), Phytothérapie (MeSH), Plasticité neuronale (MeSH), Souris (MeSH), Stress oxydatif (effets des médicaments et des substances chimiques), Synaptophysine (analyse), Taille d'organe (MeSH), Thé (MeSH), Vieillissement (MeSH).
- MESH :
- administration et posologie : Extraits de plantes.
- analyse : Facteur neurotrophique dérivé du cerveau, Homologue-4 de la protéine Disks Large, Peptides bêta-amyloïdes, Synaptophysine.
- anatomopathologie : Encéphale.
- effets des médicaments et des substances chimiques : Stress oxydatif.
- effets indésirables : Alimentation riche en graisse.
- physiopathologie : Encéphalopathies.
- traitement médicamenteux : Dysfonctionnement cognitif, Encéphalopathies.
- étiologie : Dysfonctionnement cognitif, Encéphalopathies.
- Animaux, Chimie du cerveau, Mâle, Mémoire, Neuroprotecteurs, Phytothérapie, Plasticité neuronale, Souris, Taille d'organe, Thé, Vieillissement.
English descriptors
- KwdEn :
- Aging (MeSH), Amyloid beta-Peptides (analysis), Animals (MeSH), Brain (pathology), Brain Chemistry (MeSH), Brain Diseases (drug therapy), Brain Diseases (etiology), Brain Diseases (physiopathology), Brain-Derived Neurotrophic Factor (analysis), Cognitive Dysfunction (drug therapy), Cognitive Dysfunction (etiology), Diet, High-Fat (adverse effects), Disks Large Homolog 4 Protein (analysis), Male (MeSH), Memory (MeSH), Mice (MeSH), Neuronal Plasticity (MeSH), Neuroprotective Agents (MeSH), Organ Size (MeSH), Oxidative Stress (drug effects), Phytotherapy (MeSH), Plant Extracts (administration & dosage), Synaptophysin (analysis), Tea (MeSH).
- MESH :
- chemical , administration & dosage : Plant Extracts.
- chemical , analysis : Amyloid beta-Peptides, Brain-Derived Neurotrophic Factor, Disks Large Homolog 4 Protein, Synaptophysin.
- adverse effects : Diet, High-Fat.
- drug effects : Oxidative Stress.
- drug therapy : Brain Diseases, Cognitive Dysfunction.
- etiology : Brain Diseases, Cognitive Dysfunction.
- pathology : Brain.
- physiopathology : Brain Diseases.
- Aging, Animals, Brain Chemistry, Male, Memory, Mice, Neuronal Plasticity, Neuroprotective Agents, Organ Size, Phytotherapy, Tea.
Abstract
Unhealthy diet promotes progression of metabolic disorders and brain dysfunction with aging. Green tea extracts (GTEs) have various beneficial effects and alleviate metabolic disorders. GTEs have neuroprotective effects in rodent models, but their effects against brain dysfunction in models of aging fed unhealthy diets are still unclear. Here, we showed that GTEs attenuate high-fat (HF) diet-induced brain dysfunction in senescence-accelerated mouse prone-8 (SAMP8), a murine model of senescence. SAMP8 mice were fed a control diet, HF diet, or HF diet with 0.5% GTEs (HFGT) for four months. The HF diet reduced memory retention and induced amyloid β₁-42 accumulation, whereas GTEs attenuated these changes. In HF diet-fed mice, lipid oxidative stress, assessed by malondialdehyde levels, was increased. The levels of proteins that promote synaptic plasticity, such as brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95), were reduced. These alterations related to brain dysfunction were not observed in HFGT diet-fed mice. Overall, our data suggest that GTEs intake might attenuate brain dysfunction in HF diet-fed SAMP8 mice by protecting synaptic plasticity as well as via anti-oxidative effects. In conclusion, GTEs might ameliorate unhealthy diet-induced brain dysfunction that develops with aging.
DOI: 10.3390/nu11040821
PubMed: 30979047
PubMed Central: PMC6521105
Affiliations:
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Yada, Suruga-ku, Shizuoka 422-8526, Japan. unno@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30979047</idno><idno type="pmid">30979047</idno><idno type="doi">10.3390/nu11040821</idno><idno type="pmc">PMC6521105</idno><idno type="wicri:Area/Main/Corpus">000416</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000416</idno><idno type="wicri:Area/Main/Curation">000416</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000416</idno><idno type="wicri:Area/Main/Exploration">000416</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed SAMP8 Mice.</title><author><name sortKey="Onishi, Shintaro" sort="Onishi, Shintaro" uniqKey="Onishi S" first="Shintaro" last="Onishi">Shintaro Onishi</name><affiliation wicri:level="1"><nlm:affiliation>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. oonishi.shintarou@kao.com.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497</wicri:regionArea><wicri:noRegion>Tochigi 321-3497</wicri:noRegion></affiliation></author><author><name sortKey="Meguro, Shinichi" sort="Meguro, Shinichi" uniqKey="Meguro S" first="Shinichi" last="Meguro">Shinichi Meguro</name><affiliation wicri:level="1"><nlm:affiliation>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. meguro.shinichi@kao.com.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497</wicri:regionArea><wicri:noRegion>Tochigi 321-3497</wicri:noRegion></affiliation></author><author><name sortKey="Pervin, Monira" sort="Pervin, Monira" uniqKey="Pervin M" first="Monira" last="Pervin">Monira Pervin</name><affiliation wicri:level="1"><nlm:affiliation>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. gp1747@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Kitazawa, Hidefumi" sort="Kitazawa, Hidefumi" uniqKey="Kitazawa H" first="Hidefumi" last="Kitazawa">Hidefumi Kitazawa</name><affiliation wicri:level="1"><nlm:affiliation>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. kitazawa.hidefumi@kao.com.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497</wicri:regionArea><wicri:noRegion>Tochigi 321-3497</wicri:noRegion></affiliation></author><author><name sortKey="Yoto, Ai" sort="Yoto, Ai" uniqKey="Yoto A" first="Ai" last="Yoto">Ai Yoto</name><affiliation wicri:level="1"><nlm:affiliation>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. ai_yoto@hotmail.com.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Ishino, Mayu" sort="Ishino, Mayu" uniqKey="Ishino M" first="Mayu" last="Ishino">Mayu Ishino</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16213@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Shimba, Yuki" sort="Shimba, Yuki" uniqKey="Shimba Y" first="Yuki" last="Shimba">Yuki Shimba</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16214@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Mochizuki, Yusuke" sort="Mochizuki, Yusuke" uniqKey="Mochizuki Y" first="Yusuke" last="Mochizuki">Yusuke Mochizuki</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16215@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Miura, Shinji" sort="Miura, Shinji" uniqKey="Miura S" first="Shinji" last="Miura">Shinji Miura</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. miura@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Tokimitsu, Ichiro" sort="Tokimitsu, Ichiro" uniqKey="Tokimitsu I" first="Ichiro" last="Tokimitsu">Ichiro Tokimitsu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health and Food Science, University of Human Arts and Science, Magome, Iwatsuki-ku, Saitama 339-0077, Japan. ichiro_tokimitsu@human.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Health and Food Science, University of Human Arts and Science, Magome, Iwatsuki-ku, Saitama 339-0077</wicri:regionArea><wicri:noRegion>Saitama 339-0077</wicri:noRegion></affiliation></author><author><name sortKey="Unno, Keiko" sort="Unno, Keiko" uniqKey="Unno K" first="Keiko" last="Unno">Keiko Unno</name><affiliation wicri:level="1"><nlm:affiliation>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. unno@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. unno@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nutrients</title><idno type="eISSN">2072-6643</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (MeSH)</term><term>Amyloid beta-Peptides (analysis)</term><term>Animals (MeSH)</term><term>Brain (pathology)</term><term>Brain Chemistry (MeSH)</term><term>Brain Diseases (drug therapy)</term><term>Brain Diseases (etiology)</term><term>Brain Diseases (physiopathology)</term><term>Brain-Derived Neurotrophic Factor (analysis)</term><term>Cognitive Dysfunction (drug therapy)</term><term>Cognitive Dysfunction (etiology)</term><term>Diet, High-Fat (adverse effects)</term><term>Disks Large Homolog 4 Protein (analysis)</term><term>Male (MeSH)</term><term>Memory (MeSH)</term><term>Mice (MeSH)</term><term>Neuronal Plasticity (MeSH)</term><term>Neuroprotective Agents (MeSH)</term><term>Organ Size (MeSH)</term><term>Oxidative Stress (drug effects)</term><term>Phytotherapy (MeSH)</term><term>Plant Extracts (administration & dosage)</term><term>Synaptophysin (analysis)</term><term>Tea (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alimentation riche en graisse (effets indésirables)</term><term>Animaux (MeSH)</term><term>Chimie du cerveau (MeSH)</term><term>Dysfonctionnement cognitif (traitement médicamenteux)</term><term>Dysfonctionnement cognitif (étiologie)</term><term>Encéphale (anatomopathologie)</term><term>Encéphalopathies (physiopathologie)</term><term>Encéphalopathies (traitement médicamenteux)</term><term>Encéphalopathies (étiologie)</term><term>Extraits de plantes (administration et posologie)</term><term>Facteur neurotrophique dérivé du cerveau (analyse)</term><term>Homologue-4 de la protéine Disks Large (analyse)</term><term>Mâle (MeSH)</term><term>Mémoire (MeSH)</term><term>Neuroprotecteurs (MeSH)</term><term>Peptides bêta-amyloïdes (analyse)</term><term>Phytothérapie (MeSH)</term><term>Plasticité neuronale (MeSH)</term><term>Souris (MeSH)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Synaptophysine (analyse)</term><term>Taille d'organe (MeSH)</term><term>Thé (MeSH)</term><term>Vieillissement (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Amyloid beta-Peptides</term><term>Brain-Derived Neurotrophic Factor</term><term>Disks Large Homolog 4 Protein</term><term>Synaptophysin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diet, High-Fat</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Facteur neurotrophique dérivé du cerveau</term><term>Homologue-4 de la protéine Disks Large</term><term>Peptides bêta-amyloïdes</term><term>Synaptophysine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Diseases</term><term>Cognitive Dysfunction</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Alimentation riche en graisse</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Diseases</term><term>Cognitive Dysfunction</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Encéphalopathies</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Diseases</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Encéphalopathies</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Encéphalopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aging</term><term>Animals</term><term>Brain Chemistry</term><term>Male</term><term>Memory</term><term>Mice</term><term>Neuronal Plasticity</term><term>Neuroprotective Agents</term><term>Organ Size</term><term>Phytotherapy</term><term>Tea</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chimie du cerveau</term><term>Mâle</term><term>Mémoire</term><term>Neuroprotecteurs</term><term>Phytothérapie</term><term>Plasticité neuronale</term><term>Souris</term><term>Taille d'organe</term><term>Thé</term><term>Vieillissement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Unhealthy diet promotes progression of metabolic disorders and brain dysfunction with aging. Green tea extracts (GTEs) have various beneficial effects and alleviate metabolic disorders. GTEs have neuroprotective effects in rodent models, but their effects against brain dysfunction in models of aging fed unhealthy diets are still unclear. Here, we showed that GTEs attenuate high-fat (HF) diet-induced brain dysfunction in senescence-accelerated mouse prone-8 (SAMP8), a murine model of senescence. SAMP8 mice were fed a control diet, HF diet, or HF diet with 0.5% GTEs (HFGT) for four months. The HF diet reduced memory retention and induced amyloid β₁<sub>-</sub><sub>42</sub> accumulation, whereas GTEs attenuated these changes. In HF diet-fed mice, lipid oxidative stress, assessed by malondialdehyde levels, was increased. The levels of proteins that promote synaptic plasticity, such as brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95), were reduced. These alterations related to brain dysfunction were not observed in HFGT diet-fed mice. Overall, our data suggest that GTEs intake might attenuate brain dysfunction in HF diet-fed SAMP8 mice by protecting synaptic plasticity as well as via anti-oxidative effects. In conclusion, GTEs might ameliorate unhealthy diet-induced brain dysfunction that develops with aging.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30979047</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2072-6643</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>4</Issue><PubDate><Year>2019</Year><Month>Apr</Month><Day>11</Day></PubDate></JournalIssue><Title>Nutrients</Title><ISOAbbreviation>Nutrients</ISOAbbreviation></Journal><ArticleTitle>Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed SAMP8 Mice.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E821</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/nu11040821</ELocationID><Abstract><AbstractText>Unhealthy diet promotes progression of metabolic disorders and brain dysfunction with aging. Green tea extracts (GTEs) have various beneficial effects and alleviate metabolic disorders. GTEs have neuroprotective effects in rodent models, but their effects against brain dysfunction in models of aging fed unhealthy diets are still unclear. Here, we showed that GTEs attenuate high-fat (HF) diet-induced brain dysfunction in senescence-accelerated mouse prone-8 (SAMP8), a murine model of senescence. SAMP8 mice were fed a control diet, HF diet, or HF diet with 0.5% GTEs (HFGT) for four months. The HF diet reduced memory retention and induced amyloid β₁<sub>-</sub><sub>42</sub> accumulation, whereas GTEs attenuated these changes. In HF diet-fed mice, lipid oxidative stress, assessed by malondialdehyde levels, was increased. The levels of proteins that promote synaptic plasticity, such as brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95), were reduced. These alterations related to brain dysfunction were not observed in HFGT diet-fed mice. Overall, our data suggest that GTEs intake might attenuate brain dysfunction in HF diet-fed SAMP8 mice by protecting synaptic plasticity as well as via anti-oxidative effects. In conclusion, GTEs might ameliorate unhealthy diet-induced brain dysfunction that develops with aging.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Onishi</LastName><ForeName>Shintaro</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. oonishi.shintarou@kao.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meguro</LastName><ForeName>Shinichi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. meguro.shinichi@kao.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pervin</LastName><ForeName>Monira</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. gp1747@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kitazawa</LastName><ForeName>Hidefumi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Biological Science Research, Kao Corporation, Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. kitazawa.hidefumi@kao.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoto</LastName><ForeName>Ai</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. ai_yoto@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ishino</LastName><ForeName>Mayu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16213@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shimba</LastName><ForeName>Yuki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16214@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mochizuki</LastName><ForeName>Yusuke</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. s16215@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miura</LastName><ForeName>Shinji</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. miura@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tokimitsu</LastName><ForeName>Ichiro</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Health and Food Science, University of Human Arts and Science, Magome, Iwatsuki-ku, Saitama 339-0077, Japan. ichiro_tokimitsu@human.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Unno</LastName><ForeName>Keiko</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Tea Science center, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. unno@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka 422-8526, Japan. unno@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>14-332</GrantID><Agency>Kao Corporation</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Nutrients</MedlineTA><NlmUniqueID>101521595</NlmUniqueID><ISSNLinking>2072-6643</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016229">Amyloid beta-Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000076122">Disks Large Homolog 4 Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018696">Neuroprotective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016708">Synaptophysin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013662">Tea</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016229" MajorTopicYN="N">Amyloid beta-Peptides</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001923" MajorTopicYN="N">Brain Chemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001927" MajorTopicYN="N">Brain Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019208" MajorTopicYN="N">Brain-Derived Neurotrophic Factor</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060825" MajorTopicYN="N">Cognitive Dysfunction</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000076122" MajorTopicYN="N">Disks Large Homolog 4 Protein</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008568" MajorTopicYN="N">Memory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009473" MajorTopicYN="N">Neuronal Plasticity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018696" MajorTopicYN="Y">Neuroprotective Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009929" MajorTopicYN="N">Organ Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="N">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016708" MajorTopicYN="N">Synaptophysin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013662" MajorTopicYN="Y">Tea</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">aging</Keyword><Keyword MajorTopicYN="N">green tea extracts</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword><Keyword MajorTopicYN="N">senescence-accelerated mouse prone-8</Keyword><Keyword MajorTopicYN="N">synaptic plasticity</Keyword></KeywordList><CoiStatement>The authors had no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>03</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>03</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30979047</ArticleId><ArticleId IdType="pii">nu11040821</ArticleId><ArticleId 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name="Japon"><noRegion><name sortKey="Onishi, Shintaro" sort="Onishi, Shintaro" uniqKey="Onishi S" first="Shintaro" last="Onishi">Shintaro Onishi</name></noRegion><name sortKey="Ishino, Mayu" sort="Ishino, Mayu" uniqKey="Ishino M" first="Mayu" last="Ishino">Mayu Ishino</name><name sortKey="Kitazawa, Hidefumi" sort="Kitazawa, Hidefumi" uniqKey="Kitazawa H" first="Hidefumi" last="Kitazawa">Hidefumi Kitazawa</name><name sortKey="Meguro, Shinichi" sort="Meguro, Shinichi" uniqKey="Meguro S" first="Shinichi" last="Meguro">Shinichi Meguro</name><name sortKey="Miura, Shinji" sort="Miura, Shinji" uniqKey="Miura S" first="Shinji" last="Miura">Shinji Miura</name><name sortKey="Mochizuki, Yusuke" sort="Mochizuki, Yusuke" uniqKey="Mochizuki Y" first="Yusuke" last="Mochizuki">Yusuke Mochizuki</name><name sortKey="Pervin, Monira" sort="Pervin, Monira" uniqKey="Pervin M" first="Monira" last="Pervin">Monira Pervin</name><name sortKey="Shimba, Yuki" sort="Shimba, Yuki" uniqKey="Shimba Y" first="Yuki" last="Shimba">Yuki Shimba</name><name sortKey="Tokimitsu, Ichiro" sort="Tokimitsu, Ichiro" uniqKey="Tokimitsu I" first="Ichiro" last="Tokimitsu">Ichiro Tokimitsu</name><name sortKey="Unno, Keiko" sort="Unno, Keiko" uniqKey="Unno K" first="Keiko" last="Unno">Keiko Unno</name><name sortKey="Unno, Keiko" sort="Unno, Keiko" uniqKey="Unno K" first="Keiko" last="Unno">Keiko Unno</name><name sortKey="Yoto, Ai" sort="Yoto, Ai" uniqKey="Yoto A" first="Ai" last="Yoto">Ai Yoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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